Induction and characterization of monoclonal anti-idiotypic antibodies reactive with idiotopes of canine parvovirus neutralizing monoc!onal

Rimmelzwaan, G.F., van Es, J.H., Drost, G., UytdeHaag, F.G.C.M. and Osterhaus, A.D.M.E., 1991. Induction and characterization of monoclonal anti-idiotypic antibodies reactive with idiotopes of canine parvovirus neutralizing monoclonal antibodies. Vet. Immunol. Immunopathol., 29:139150. Monoclonal anti-idiotypic (anti-ld) antibodies (Ab2) were generated against idiotypes (ld) of canine parvovirus (CPV) specific monoclonal antibodies (MoAbs). The binding of most of these anti-Id antibodies to their corresponding Id could be inhibited by antigen, thus classifying these antiid antibodies as Ab2~, or Aozp. b y m m m u n g e x p e r i m e n t s i t w a a a n u w . m a t u i ~ . . . . . . . . . . . . . . . . . . . did not recognize interspecies cross-reactive idiotopes, but recognized private idiotopes, uniquely associated with the Id of the anti-CPV MoAb used for immunization. This classifies these anti-ld antibodies as non-internal image Ab2y. The potential use of these non-internal image anti-ld antibodies for the induction of antiviral antibodies in the CPV system is discussed.